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TMED-105 Pathologic Basis of Disease, 1-3 cr 
Code TMED-105  Validity 01.01.2017 -
Name Pathologic Basis of Disease  Abbreviation Pathologic Basi 
Scope1-3 cr   
TypeAdvanced studies
TypeStudy block/Line   
  GradingGeneral scale 
Unit Master's Programme in Translational Medicine 

Sanna Lehtonen 

Target group 

Students of the Master’s Degree Programme in Translational Medicine (TRANSMED) (TMED-105A, 3 cr) and doctoral students (TMED-105B, 1cr)


Period II, second study year for TRANSMED students. Arranged for the first time in autumn 2018

Learning outcomes 

After the course, the student will understand the general mechanisms underlying and leading to human disease and will understand and be able to describe general features and relevant molecular mechanisms of the most important organ pathologies.

Completion methods 

TMED-105A (3 credits, TRANSMED students): Completion requires at least 80% participation in the lectures and other course activities and a passing grade on the exam, which will be based on lectures and the self-study material.

TMED-105B (1 credit, non-TRANSMED students): Completion requires at least 80% participation in the lectures and writing a learning diary of all the lectures.


TMED-105A (3 cr):  TMED-909 Human Anatomy and Physiology or similar


Lectures will cover the general pathophysiological mechanisms of disease (general pathology) and the diagnostically and therapeutically relevant features of several important diseases (“organ pathology”). During theme days, the students will become familiar with the basic diagnostic methods of anatomic and molecular pathology through case studies. Each theme day includes demos and laboratory visits, including an excursion to the pathology laboratory of HUSLAB that provides pathology services for Helsinki University Hospital.

Lecturers: Olli Carpén, Sanna Lehtonen, Tuomas Mirtti, Mikko Mäyränpää, Tobias Freitag, Liisa Myllykangas, Hannu Sariola

Organisers for the demos: Helena Leijon, Liisa Myllykangas, Mikko Mäyränpää

Lectures 16 h
Visits/demos (TRANSMED students only): 6 h
Self-study 11 h (1 cr option) or 47 h (3 cr option)
Exam (TRANSMED students only) 2 h

Study materials and literature 

TMED-105A (3 credits, TRANSMED students): Lecture materials and eBook: Robbins, Basic Pathology (selected parts)

TMED-105B (1 credit, non-TRANSMED students): Lecture materials

Activities and teaching methods in support of learning 

The course combines self-study, lecture-based teaching and practical case studies to enhance learning and the collecting of knowledge, aiming for a greater understanding of the key concepts and principles of the pathophysiological mechanisms of disease. The learning diary deepens the understanding of the contents of the lectures and helps the student to gain competence in verbally communicating the gained knowledge.

Teachers communicate with each other when preparing for the course and during the teaching, and collect feedback from each other and from the students.

Assessment practices and criteria 

TMED-105A: Grading scale 0–5. Grading is based on the exam.

TMED-105B: Pass/fail. Grading is based on the learning diaries.

Relations to other study units 

TMED-105A replaces course 30472 Pathologic Basis of Disease


Current and future instruction
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Future examinations
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